Need a little more information.
Where are you pinging from? What are all the network parameters of that end point? (all NICs, what Workstation networks each connects to, all IP settings of any vmkernel port)
If the ESXi server, what ping command? (ping, vmkping)
If ESXi, what version?
Where are you pinging? What are all the network parameters of that end point? (all NICs, Workstation networks, IP settings)
If you have made a change that broke the environment, does undoing the change fix it?